In the aftermath of the Festum's attack on Hawaii, Hester ordered the ROE Alpha protocol to be carried out regardless of the civilians and Human Army personnel presented on the battlefield. She later oversaw the movements of the refugee convoy leaving Srinagar, sending their location to the Aviator through the Prometheus Core so that the Festum would destroy the convoy.
After Maya Toumi was captured, she was brought before Hester, who declared her intention of having Maya piloting the Mark Raison. She also showed a degree of fondness toward Maya because the girl reminded her when she was still young. Hester wished for Maya to join her in the quest to wipe out the Festum on Earth.
The Prometheus Core later betrayed Hester and took control of the puppets. It also made a deal with Dudley Burns, who would control Human Army force as its proxy. Hester however was able to escape from the island, and was last seen watching the Fourth Operation Azure unfolded.